Problems in Protein Biosynthesis

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Problems in Protein Biosynthesis

Outline of the steps in protein synthesis. Nature of the genetic code. The use of synthetic oligo- and polynucleotides in deciphering the code. Structure of the code: relatedness of synonym codons. The wobble hypothesis. Chain initiation and N-formyl-methionine. Chain termination and nonsense codons. Mistakes in translation: ambiguity in vitro. Suppressor mutations resulting in ambiguity. Limit...

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Techniques in Protein Biosynthesis

The large number and variable quality of recent research papers in the field of protein biosynthesis often has made it difficult for readers to discern clearly the experimental basis (or lack thereof) of the interpretation put on the results that are presented. A new series of volumes has been initiated, therefore, to provide critical discussions of the methods used in this active area of bioch...

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Techniques in Protein Biosynthesis

This book is volume 2 in a series intended to introduce methods used in the study of protein biosynthesis. The present volume includes chapters on the genetic approach to the study of protein biosynthesis in plant systems, analysis of polysomes, fractionation of ribosomal proteins, animal operative techniques, and the use of sources of high energy phosphate. Inevitably, there is overlap with st...

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Integral membrane protein biosynthesis

Understanding the details of integral membrane protein biogenesis is important for the study of any process or pathway that involves these proteins, including signaling cascades, vesicle trafficking and intercellular communication. Structural information is commonly used to predict protein function, and an important feature of the tertiary structure of an integral membrane protein is its topolo...

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The frequency of errors in protein biosynthesis.

Anson, M. L. (1938). J. gen. Physiol. 22, 79. Brown, P. C., Consden, R. & Glynn, L. E. (1958). Ann. Rheum. Di8. 17, 196. Dawson, A. B. (1946). Amer. J. Anat. 79, 241. Dingle, J. T. (1962). Proc. roy. Soc. Med. 55, 109. Frankland, D. M. & Wynn, C. H. (1962). Biochem. J. 85, 276. Harkness, M. L. R. & Harkness, R. D. (1954). J. Physiol. 123, 492. Harkness, R. D. & Moralee, B. E. (1956). J. Physiol...

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ژورنال

عنوان ژورنال: Journal of General Physiology

سال: 1966

ISSN: 1540-7748,0022-1295

DOI: 10.1085/jgp.49.6.305